When do San Francisco 49ers play next? NFL Week 2 schedule, opponent

The San Francisco 49ers played their NFL Week 1 game against the Los Angeles Rams on Thursday, Sept. 10, 2026, in Melbourne, Australia.

When do the 49ers play next on the 2026 NFL schedule?

Where will San Francisco play in NFL Week 2?

Who do the San Francisco 49ers play next in their Week 2 NFL game?

Here’s what to know about the upcoming schedule for Brock Purdy, Christian McCaffrey, George Kittle, Fred Warner and the San Francisco NFL team’s Week 2 game.

NFL Week 1 predictions: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Picks, win probabilities

Watch next 49ers game on FUBO (free trial)

The San Francisco 49ers will play in NFL Week 2 of the 2026 NFL season on Sunday, Sept. 20, 2026. The game is scheduled to start at 1:25 p.m. MST (4:25 p.m. ET) and can be seen on FOX.

NFL Week 1 picks: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | The Republic’s predictions

The 49ers will play their NFL Week 2 game at home at Levi’s Stadium in Santa Clara, California.

NFL Week 1 odds: Patriots vs Seahawks | 49ers vs Rams | Bears vs Panthers | Buccaneers vs Bengals | Saints vs Lions | Bills vs Texans | Ravens vs Colts | Browns vs Jaguars | Falcons vs Steelers | Jets vs Titans | Cardinals vs Chargers | Dolphins vs Raiders | Packers vs Vikings | Commanders vs Eagles | Cowboys vs Giants | Broncos vs Chiefs | Point spreads, moneylines, over/unders

The 49ers will play the Miami Dolphins in their NFL Week 2 game.

Where are the San Francisco 49ers?

TV channels, how to watch, how to stream games

NFL’s highest paid players in 2026: Quarterbacks | Running backs | Wide receivers | Tight ends | Offensive linemen | D-linemen | Cornerbacks | Safeties | Linebackers | Edge rushers | Overall | By position | By team

Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: When do San Francisco 49ers play next? NFL Week 2 schedule, opponent

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