Cardinals vs. 49ers predictions: Spread, Total, and 3 Bold Picks!

Nairavoice | Sep 26, 2026 2h ago 201 0 3 min read

Cardinals vs. 49ers predictions: Spread, Total, and 3 Bold Picks!

For the Arizona Cardinals, this weekend is a big one.

No, it won’t determine the season, but showing progress, rebounding from a tough loss and getting ready for the last 14 games will help fans stay engaged.

If the Cardinals struggle to cover the +8.5-point line and end up getting blown out for the second straight week against a division opponent, then fans may find the bandwagon emptying for 2026.

I think this one could be an explosive offensive back and forth, but the Cardinals have to handle their side of things on offense.

Here are three plays from FanDuel Sportsbook I like in this one.

I know, I know this is a big one, but I think both of these guys have big games and the offenses in general should be able to put up points.

McBride has 23 targets in two games, and while the eight receptions last week didn’t do a lot in terms of yardage, but we know the opportunities will be there.

Kittle has not done a ton this year, but the Cardinals defense looked bad in the second half last week, and the Niners offense has been humming through two games. This is a longshot, but it is a fun one.

The only concern for this one is if it does get sideways will the Niners keep running him out there. I really expect this to be competitive, maybe hope is a better word but I think the Cardinals can hang and force a back and forth, which means McCaffrey will be getting his touches.

Through two games the one thing we can say about the offense is it does not score touchdowns. Now, in the loss to the Seahawks it didn’t score field goals, but I am trying to see that last week was an aberration and in doing so I think the Cardinals are able to move the ball and score points. Maybe just not touchdowns yet.

This is my week. Not in the sense that I won’t believe in the team, etc. but in the sense that I really think last week was a fluke. I think this team is better, not necessarily good, but better and that they will compete and make this a one score game.

Make game day even better with live chat, faster conversations and all your favorite communities in one place.