Few Pokémon have captured fans’ imaginations quite like Mewtwo. From its debut in Pokémon Red & Blue as a fearsome level 70 legendary lurking deep within Cerulean Cave to its memorable turn as the eloquent, existentially troubled antagonist of 1998’s Pokémon: The First Movie, the Genetic Pokémon has enjoyed a particularly notable place in franchise history. Throw in two distinct Mega Evolutions and nearly three decades of appearances, and Mewtwo’s enduring popularity seems fairly understandable. For a Pokémon created in a laboratory, Mewtwo has proved remarkably difficult to replicate.
That popularity extends to the Pokémon TCG, where Mewtwo has appeared on everything from nostalgic vintage holos, gorgeously textured Special Illustration Rares, and extraordinarily scarce promotional cards. And while plenty of Mewtwo cards can be acquired without breaking the bank, the character’s most coveted cardboard incarnations command truly staggering sums. Some are so valuable that even Giovanni might have second thoughts about footing the bill.
Let’s explore the 10 most valuable Mewtwo Pokémon cards of all time.
10
First Edition Shadowless Holo Mewtwo – Base Set
Market Price: $403.22
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Image via The Pokémon Company</figure>
There’s no better place to start than with the very first English-language Mewtwo card, the highly sought-after First Edition Shadowless Base Set Holo Mewtwo with art from original Pokémon designer and illustrator, the inimitable Ken Sugimori.
The first two English print runs of the Pokémon TCG’s original Base Set lacked the dark drop shadows along the right and bottom edges of each Pokémon’s artwork frame, a subtle design quirk collectors now call “Shadowless.” Both 1st Edition cards and the subsequent unstamped print run shared this distinction, though the latter is typically what collectors mean when referring to Shadowless cards.
Of course, that tiny little “Edition 1” stamp is where the truly immense value is contained among the game’s first set, and First Ed. Base Set Mewtwo’s over-$400 price tag gives you a good understanding of just how valuable the cards on this list will be.
9
Holo Mewtwo (Staff Stamped) – Evolutions
Market Price: $505.11
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Image via The Pokémon Company</figure>
The PTCG’s Evolutions expansion released in 2016 and represented something of a 20th anniversary celebration of the franchise, with a distinct focus on the TCG itself. As has been seen with cards from the eminently popular 30th Celebration expansion, anniversary sets in the TCG often represent hot commodities, and that is surely the case with this now 10-year-old set.
Featuring identical artwork to the original Base Set Mewtwo, this card’s stats, attacks, and effects were all altered to make it a bit more playable in 2016. This over-$500 variant of the card was one of four special holographic promos, alongside Charizard, Gyarados, and Machamp, distributed during Evolutions prerelease tournaments in October 2016. Players attending these events received a prerelease kit containing one of the four cards, each bearing a distinctive Evolutions logo stamped on its artwork.
However, an even scarcer version was reserved for those running the show. These special variants featured an additional gold “STAFF” stamp in the lower-left corner of the illustration and were distributed separately to tournament organizers, judges, and other event staff rather than ordinary participants. With considerably fewer copies entering circulation, these Staff-stamped cards have become (understandably) particularly coveted among collectors.
8
First Edition Holo Rocket’s Mewtwo – Gym Challenge
Market Price: $537.65
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Image via The Pokémon Company</figure>
With its immense power, occasionally murky motivations, and a backstory rooted in some of the Pokémon franchise’s earliest mysteries, Mewtwo has often found itself aligned with some of the Pokémon franchise’s less savory characters. Perhaps its most lucrative partnership (at least for collectors) has been with the dastardly Team Rocket, an organization notorious for exploiting Pokémon with little regard for their health or well-being.
That uneasy alliance has resulted in several highly valuable Trainer’s Pokémon cards featuring the villainous gang. The first of these cards on our list hails from 2000’s Gym Challenge expansion, which continued the Trainer-focused theme of its predecessor, Gym Heroes.
Beyond this being the first Rocket’s Mewtwo card ever printed, perhaps more notably, this was the first Pokémon card ever printed that featured three distinct attacks — which is still a highly unusual category from a game that has printed well over 20,000 cards in English.
7
Holo Mewtwo GX (Secret Shining) – Shining Legends
Market Price: $621.78
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Image via The Pokémon Company</figure>
Mitsuhiro Arita is responsible for illustrating arguably the most iconic Pokémon card of all time: the fire-breathing masterpiece that is Base Set Charizard. Beyond that beauty, the venerable artist has contributed hundreds of illustrations to the TCG over the decades, with his work continuing to appear in most of the game’s recent expansions, including 2026’s 30th Celebration anniversary set.
One of Arita’s finest illustrations was tucked away as a Secret Rare in 2017’s Shining Legends special expansion: Mewtwo GX (78/73). Nicknamed “Mewtube” by collectors, this stunning full-art illustration showcases an ominously menacing Mewtwo suspended inside a laboratory containment tank, seemingly moments away from breaking free and exacting revenge on its creators.
It’s an extraordinary piece of artwork, and one that goes a long way toward explaining its lofty, over-$600 price point.
6
Holo Team Rocket’s Mewtwo ex – Team Rocket Returns
Market Price: $647.85
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Image via The Pokémon Company</figure>
The second of three Team Rocket’s Mewtwo variants herein, this one hails from the utterly grail-filled EX-era set, 2004’s Team Rocket Returns. While the set is likely better known among PTCG connoisseurs as the home of some incredibly scarce Gold Star cards (in this case, the Hoenn starter trio of Mudkip, Torchic, and Treecko), it also housed a stable of immensely valuable, and stunning, Team Rocket’s Pokémon, including this Darkness-type Mewtwo variant.
One of only four Mewtwo cards that are not Psychic-type in the TCG, this ultra-rare offering boasts several distinguishing features. First, its Darkness typing makes it highly unusual among Mewtwo printings. Second, it features a unique computer-generated art style by none other than Mitsuhiro Arita, something the decorated PTCG illustrator is not particularly known for. Third, it boasts three attacks, something already mentioned as uncommon.
Lastly, Pokémon ex cards from this era are particularly difficult to find in pristine condition, and they boast a stunning holofoil finish that extends all the way to the card’s silver border, making them particularly striking when displayed in a frame or your beloved binder. With all that in mind, nearly $650 for a piece of more than 20-year-old cardboard starts to make a little more sense.
5
Holo Team GR’s Mewtwo – Japanese Game Boy Promo
Market Price: $668.73
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Image via The Pokémon Company</figure>
While the majority of this list revolves around English-language Pokémon cards, one Japanese-exclusive oddity sits comfortably in the middle: the ultra-rare Game Boy promo featuring Team GR’s Mewtwo, complete with distinctive artwork by Shin-ichi Yoshida. Originally released on March 28, 2001, this holographic beauty was included alongside an equally stunning Lugia promo in Japanese copies of Pokémon Card GB2: Here Comes Team GR!, a Game Boy Color sequel that, rather disappointingly, never received an official international release following the first Pokémon Trading Card Game video game.
Unlike traditional booster-pack offerings, this Mewtwo could only be obtained by purchasing the game, and its distinctive “GB” expansion symbol serves as a reminder of its unusual origins. More than 25 years later, this peculiar piece of Pokémon history commands nearly $670 on the secondary market, proving that sometimes the best video game bonuses aren’t found on-screen.
4
Reverse Holo Mewtwo – Legendary Collection
Market Price: $984.00
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Image via The Pokémon Company</figure>
The Reverse Holofoil cards found in the TCG’s 2002 Legendary Collection set (dubbed “fireworks” due to their distinctive foiling pattern) are among the scarcest and most valuable vintage Pokémon cards of all time, with highly graded copies of certain cards even fetching seven figures.
When you combine that pedigree with artwork that was previously exclusive to a Wizards Black Star Promo, it’s no wonder this Legendary Collection Reverse Holo Mewtwo represents a significant spike in value between and herein.
Even more intriguing, this card is one of the few in the TCG that shares DNA with Magic: The Gathering. Christopher Rush illustrated this Mewtwo, and the beloved late artist was also responsible for much of Magic‘s early artistic identity, including its mana symbols and, perhaps more importantly for collectors, the artwork for the iconic Black Lotus.
This intriguing confluence of factors contributes to the card’s nearly four-digit valuation.
3
Reverse Holo Rocket’s Mewtwo (Winner) – Best of Promo
Market Price: $1,019.54
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Image via The Pokémon Company</figure>
While this card is mechanically and artistically identical to the original Gym Challenge version before it, this version is worth nearly double that of its first printing. But why?
Well, perhaps it’s due to its unusual distribution history. This card was originally intended as a promotional prize for Wizards of the Coast’s BattleZone tournaments in June 2003, featuring a distinctive gold “winner” stamp in the lower-right corner of its artwork. However, Wizards lost its Pokémon TCG license before the events could take place, resulting in their cancellation.
Fortunately for collectors, some tournament prize kits had already been shipped to organizers, allowing these promos to enter circulation despite never receiving their intended release. Unlike earlier Best of Game promos, this Mewtwo never received a standard, non-Winner printing.
Or perhaps its full-card Reverse Holofoil finish, replete with stunning swirls, winding whorls, and various other flashy foil elements, is simply too enjoyable to resist. Apparently, over $1,000 is the going rate for such a striking piece of Pokémon card art.
2
First Edition Holo Shining Mewtwo – Neo Destiny
Market Price: $2,264.26
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Image via The Pokémon Company</figure>
The eminently scarce Shining cards from 2002’s Neo Destiny feature Charizard, Raichu, Noctowl, Celebi, Tyranitar, Kabutops, Steelix, and, of course, Mewtwo. These secret rares were supremely coveted upon release, and their nearly mythical status has only grown over the ensuing decades as collectors continue to shell out eye-popping sums for pristine vintage Pokémon cards.
In such an environment, it makes perfect sense that Shining Mewtwo, especially in a First Edition printing, would rank among the most valuable Mewtwo cards ever. Adding to its historical significance is the fact that Neo Destiny was the final English-language Pokémon TCG expansion to receive the iconic First Edition stamp, making this particular printing especially desirable. Ultimately, Shining Mewtwo just misses out on the top spot thanks to an equally elusive Mewtwo chase card.
Perhaps most striking about Shining Mewtwo is its unusual holographic treatment. Rather than applying the familiar holofoil finish to the background of the artwork, the creators of the Shining cards flipped the formula on its head, giving the Pokémon themselves a reflective metallic finish against otherwise non-holographic backdrops. The result is a wonderfully distinctive effect that makes Shining Mewtwo positively gleam when viewed from different angles, representing one of the most memorable visual flourishes of the entire Wizards of the Coast era.
For such a lofty price tag, you’d expect one of the most desirable and striking Pokémon cards ever printed. With First Edition Shining Mewtwo, you certainly get one.
1
Holo Mewtwo Gold Star – Holon Phantoms
Market Price: $2,612.30
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Image via The Pokémon Company</figure>
As you might expect, combining the coveted Gold Star treatment with Mewtwo, one of the most popular and powerful ‘mon ever, makes for an utterly spectacular card with a truly wallet-obliterating price point. And that’s before you even begin to delve into graded copies.
Released in 2006, Holon Phantoms featured three Gold Star cards: Gyarados, Pikachu, and Mewtwo. Originally introduced in 2004’s Team Rocket Returns, Gold Stars were exceptionally difficult to pull from booster packs, with commonly cited estimates suggesting roughly one per two booster boxes. These cards featured Shiny Pokémon, a distinctive gold star beside their names, and artwork that extended beyond the traditional illustration frame.
A number of extraordinarily valuable Gold Star Pokémon cards have changed hands over the past year, but Mewtwo Gold Star retains a certain cachet among collectors thanks to its scarcity, popularity, and immediately recognizable artwork courtesy of Masakazu Fukuda (the artist responsible for illustrating every Gold Star card in the TCG) showcasing a Shiny Mewtwo emerging from a cosmic backdrop, with its imposing figure extending beyond the artwork’s borders.
Oh, and graded copies? A PSA 10 example attracted 37 bids and reached an astonishing record price of $312,000 during Fanatics Collect’s October 25 auction. With just 128 examples earning PSA’s coveted Gem Mint grade, securing one in such pristine condition is no small feat.
So, yes, Pokémon cards can make for spectacular investments, provided you’re fortunate enough to find the best. Fitting for a franchise built around the idea of “wanting to be the very best.”
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