Prediction: Liverpool vs Atletico Madrid

Two camps who will get their respective Champions League adventures underway on Wednesday night, Liverpool will welcome Atletico Madrid to Anfield.

Ahead of a stacked Wednesday of European action, there are plenty of eye-catching Champions League betting promotions available.

Verdict: Alexander Isak over 0.5 shots on target

Liverpool

Starting with the hosts, while Liverpool might have opened up the 2026/27 campaign with consecutive 2-2 stalemates against Newcastle and Nottingham Forest, Andoni Iraola finally claimed a maiden Anfield victory over the weekend. Landing a 2-0 win away at Premier League newcomers Ipswich, the former Bournemouth boss will be calling on his squad to use that professional display as a platform to build on. Clinching a first domestic win since the end of April, Liverpool will take some solace from their overall success on home soil. Despite signing off August with that action-packed 2-2 draw against Forest, Liverpool have suffered just a sole competitive defeat in front of their own supporters since the start of February. Likewise, Iraola’s new squad also landed a 3-2 victory when they welcomed Atletico to Anfield for a Champions League showdown 12 months ago.

All still recovering from respective long-term injury issues, Liverpool will once again be without the trio of Conor Bradley, Joe Gomez and French striker Hugo Ekitike on Wednesday night. Completing a record-breaking Deadline Day switch to Anfield, Bradley Barcola could make his full debut for Iraola’s side.

Left as an unused substitute away at Ipswich on Friday night, former Bayer Leverkusen defender Jeremie Frimpong will be hoping for a full recall. Bagging both goals at Portman Road over the weekend and already registering three Premier League strikes so far this season, Alexander Isak will lead the line.

Atletico Madrid

As for the visitors, while Atletico Madrid might have enjoyed an eye-catching start to the 2026/27 campaign, Diego Simeone’s side came crashing back down to earth over the weekend. Completely blown away in the Basque Country as they slumped to a 3-0 drumming against Athletic Bilbao, the Spanish giants are desperately searching for an immediate response here. Signing off last season with a nightmare 5-1 defeat against Villarreal back on May 24th, Madrid have failed to find any kind of defensive stability on either side of the summer interval. In fact, Simeone’s men have registered just a trio of clean sheets from any of their previous 16 consecutive appearances across all competitions – a run that stems back to the start of April.

Yet to make a single appearance after suffer a muscle injury during Atletico’s summer preparations, Simeone’s side are once again expected to be without Norwegian international Alexander Sorloth. Completing a Deadline Day switch from Juventus, Canadian marksman Jonathan David should make his Atletico debut here.

Eventually staying put in the Spanish capital following what was an infamous summer transfer saga, wantaway striker Julian Alvarez could make a first start of the season. Enjoying a bright start to life in the Spanish capital, former PSG star Kang-In Lee could be deployed in a deeper role.

Liverpool vs Atletico Madrid Key Factors to Consider

• When Liverpool welcomed Atletico Madrid to Anfield for a Champions League group stage showdown 12 months ago, Wednesday’s hosts claimed an action-packed 3-2 victory.
• In fact, Liverpool have won all of their last four consecutive European battles against Atletico.
• Liverpool have suffered just a sole competitive defeat in front of their own supporters since the start of February.
• Atletico Madrid have registered just a trio of clean sheets from any of their previous 16 consecutive appearances across all competitions – a run that stems back to the start of April.
• Swedish international Alexander Isak has notched three goals in 154 minutes of Premier League action over the past week.

With Iraola getting a maiden Liverpool victory under his belt on Friday night thanks to a 2-0 win away at Ipswich, the Reds will be desperate to open their Champions League adventure with an early statement. Securing an action-packed 3-2 victory when they welcomed Atletico to Anfield for a group stage showdown 12 months ago, Liverpool hold a dominant record against Wednesday’s guests. In fact, winning all of their last four straight Champions League battles against Los Rojiblancos, we could be treated to another enjoyable European battle from Merseyside.

Verdict: Alexander Isak over 0.5 shots on target

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