Winger Doku set up Arsenal forward Leandro Trossard for the first on 28 minutes and former Blue Kevin De Bruyne for the third on 65 minutes.
Atalanta striker Charles De Ketelaere scored the second on 53 minutes in between times while the task was made easier for the hosts when Tunisia and FC Augsburg winger Ismaël Gharbi was dismissed just past the hour mark after the second bookable offence.
Further efforts from Benfica winger Dodi Lukebakio and Rangers midfielder Nicolas Raskin in the final five minutes ensured a comprehensive victory at King Baudouin Stadium in Brussels.
Doku played 74 minutes in total before being replaced by Lille forward Matias Fernandez-Pardo.
Rudi Garcia’s side will now head to the United States ahead of the 2026 tournament, with Belgium starting with a Group G clash against Omar Marmoush’s Egypt at Seattle’s Lumen Field on Monday 15 June, kick-off 20:00 (UK).
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